Top Florence Hotels Conveniently Located off I-95

We checked thousands of reviews on and to find the best hotels for your stay
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Valentina Wright

Updated: 26 August 2024 · 3 min

Nestled in the heart of South Carolina, Florence beckons travelers with its charming southern hospitality and picturesque landscapes. As you embark on your journey to this vibrant city, the quest for accommodations that offer convenience and comfort is paramount. Consider exploring the plethora of Florence SC hotels located just off the bustling I-95 highway, providing easy access to the city's attractions and amenities. From budget-friendly options to luxurious stays, there is a diverse array of lodging choices catering to every traveler's needs.

Immerse yourself in the rich tapestry of Florence's culture and history, with its historic downtown district offering an array of dining, shopping, and entertainment venues. After a day of exploration, returning to a cozy retreat just off I-95 can provide the perfect sanctuary to unwind and recharge. Select a hotel that suits your preferences, whether you prefer a modern hotel with state-of-the-art amenities or a charming bed-and-breakfast exuding southern charm. The convenience of staying near I-95 ensures seamless travel arrangements and easy access to other nearby attractions.

Venture beyond the confines of your hotel to discover the hidden gems of Florence, from strolling through serene parks to delving into the local arts scene. Additionally, being situated off I-95 serves as a strategic base for day trips to nearby cities or historic sites, allowing you to maximize your time in this enchanting region. With a mix of comfort, convenience, and accessibility, choosing one of the Florence SC hotels off I-95 promises to enhance your travel experience and create lasting memories in this captivating Southern destination.
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Our Top 6

(Sorted by rating & number of reviews)

1. The Stricklin Hotel- Florence
2. Baymont By Wyndham Florence/Muscle Shoals
3. Waterfront Florence Home W/ Private Dock!
4. Holiday Inn Express Florence Northeast By Ihg
5. Gunrunner Boutique Hotel
6. Comfort Suites Florence Shoals Area

Top Picks for Florence SC Hotels off I-95

Check Availability

Florence
May 20, 2026 - May 21, 2026

The Stricklin Hotel- Florence

7.4

Good

(97 Reviews)

+ 34 photos
Combining historic charm with modern comfort, The Stricklin Hotel is a boutique gem conveniently situated off I-95 in Florence. Guests can experience luxury accommodations, fine dining options, and personalized service in this elegant hotel. The hotel's prime location near I-95 makes it a sought-after destination for discerning travelers seeking a unique and upscale experience in Florence.
Address: 317 North Court Street
Rating: Good 7.4 (97 Reviews)
Rooms: 26
Price: From 149$

Baymont By Wyndham Florence/Muscle Shoals

6.4

Good

(478 Reviews)

+ 77 photos
Situated just off I-95, Baymont By Wyndham Florence/Muscle Shoals offers cozy rooms and modern amenities for a comfortable stay. Guests can enjoy complimentary breakfast, on-site fitness center, and easy access to nearby dining and shopping options. With its convenient location off the highway, this hotel is a popular choice for travelers looking for a relaxing overnight pitstop in Florence.
Address: 115 Ana Dr
Rating: Good 6.4 (478 Reviews)
Rooms: 64
Price: From 76$

Boutique Stays at Florence SC Hotels off I-95

For those seeking a more intimate and unique accommodation experience, these boutique hotels near I-95 in Florence offer personalized service and distinctive charm. Each property exudes its own character, providing a cozy and memorable stay for discerning travelers. Escape the ordinary and immerse yourself in the bespoke hospitality of these boutique stays just off the I-95 highway in Florence.

Waterfront Florence Home W/ Private Dock!

8.0

Good

(1 Reviews)

+ 33 photos
This stunning waterfront home near I-95 offers guests a slice of paradise with its private dock, spacious accommodations, and breathtaking views of the water. Ideal for outdoor enthusiasts and those seeking a tranquil retreat, this property provides a unique stay experience in Florence. With its convenient location off I-95, guests can easily access the city's attractions while enjoying a serene waterfront escape.
Address: 710 Lakeside Dr
Rating: Good 8.0 (1 Reviews)
Price: From 142$

Holiday Inn Express Florence Northeast By Ihg

8.7

Good

(222 Reviews)

+ 54 photos
Nestled just off I-95, Holiday Inn Express Florence Northeast offers modern accommodations and exceptional service to ensure a relaxing stay for guests. Visitors can enjoy amenities such as a complimentary hot breakfast, 24-hour fitness center, and easy access to local attractions. With its convenient location off the highway, this hotel is a popular choice for travelers exploring the vibrant city of Florence.
Address: 180 Etta Gray Street
Rating: Good 8.7 (222 Reviews)
Rooms: 79
Price: From 169$

Unique Lodging Options near Florence SC off I-95

For travelers seeking distinctive and unconventional accommodations, these unique lodging options near I-95 in Florence offer a one-of-a-kind stay experience. From cozy apartments to waterfront homes, these properties provide a blend of comfort and creativity, perfect for those looking for a memorable escape. Explore these offbeat lodging choices near I-95 for a truly unique adventure in Florence.

Gunrunner Boutique Hotel

9.0

Good

(16 Reviews)

+ 91 photos
Nestled near I-95, the Gunrunner Boutique Hotel is a hidden gem offering luxurious accommodations and a serene ambiance for guests. With distinctive decor and upscale amenities, this boutique hotel provides a sophisticated retreat in Florence. Guests can savor gourmet dining experiences, relax in the cozy lounge areas, and enjoy personalized service during their stay.
Address: 310 East Tennessee Street
Rating: Good 9.0 (16 Reviews)
Rooms: 34
Price: From 321$

Comfort Suites Florence Shoals Area

8.5

Good

(265 Reviews)

+ 91 photos
Conveniently located near I-95, Comfort Suites Florence Shoals Area boasts spacious suites and top-notch facilities, ideal for both business and leisure travelers. Guests can unwind in the indoor pool, stay connected with free Wi-Fi, and indulge in a complimentary hot breakfast. The hotel's proximity to I-95 makes it a convenient choice for those seeking a peaceful retreat in Florence.
Address: 140 Matthew Paul Court
Rating: Good 8.5 (265 Reviews)
Rooms: 68
Price: From 127$